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Publications associées (10)

Development of methods for the synthesis of large combinatorial libraries of macrocyclic compounds

Macrocycles have raised much interest in the pharmaceutical industry due to their ability to bind challenging targets while often still being able to cross membranes to reach intracellular proteins. However, the development of macrocyclic ligands to new di ...

EPFL2023

Repetitive regime of highly focused liquid microjets for needle-free injection

Christophe Moser, Paul Delrot, Jan Krizek

Fast liquid jets are investigated for use as a needle-free drug delivery system into an elastic tissue such as skin. Using smaller jet diameters in a repetitive regime can mitigate bruising and pain associated with current injectors. In this study, we aim ...

2020

Facile Fabrication of Microfluidic Chips for 3D Hydrodynamic Focusing and Wet Spinning of Polymeric Fibers

Fabien Sorin, René M. Rossi, Efe Armagan, Claudio Toncelli, Akin Gürsoy

Microfluidic wet spinning has gained increasing interest in recent years as an alternative to conventional wet spinning by offering higher control in fiber morphology and a gateway for the development of multi-material fibers. Conventionally, microfluidic ...

2020

Needle for invasive medical use and needle assembly

Simon Nessim Henein, Charles Baur

A needle for invasive medical use includes a long extended cylindrical needle shaft having an axis and an outer surface area, with a short shaft end at a first end of the shaft with a beveled tip with a pointed end, and a needle hub attached to a second en ...

2016

Injection Device

Yves Perriard, Romain David Besuchet

An injection deviee for injecting injection material, comprising: an elastic deformable element (3) able to exert a pushing force on a piston (20) of a syringe (2) so as to eject a quantity of injection material out of the syringe (2); a stopper ( 4) for r ...

Juvaplus SA, Neuchâtel (CH)2015

Experiments in a novel quasi-1D diffusion flame with variable bulk flow

Peter Monkewitz, Etienne Robert

The novel species injector of a recently developed research burner, consisting of an array of hypodermic needles, which allows to produce quasi one-dimensional unstrained diffusion flames has been improved. It is used in a new symmetric design with fuel an ...

2009

Experimental investigation of unstrained diffusion flames and their instabilities

Etienne Robert

In this thesis, thermal-diffusive instabilities are studied experimentally in diffusion flames. The novel species injector of a recently developed research burner, consisting of an array of hypodermic needles, which allows to produce quasi one-dimensional ...

EPFL2009

Integration of a microfluidic flow cell on a CMOS biosensor for DNA detection

Nico de Rooij, Peter Van der Wal

This paper describes the fabrication technique for the realization a microfluidic flow cell to be integrated on a CMOS biosensor for DNA hybridization detection. The main element of the microfluidic system is made in polydimethylsiloxane (PDMS) elastomer a ...

IEEE Service Center, 445 Hoes Lane, Po Box 1331, Piscataway, Nj 08855-1331 Usa2008

Impaired expression of the peroxisome proliferator-activated receptor alpha during hepatitis C virus infection

Johan Auwerx, Kristina Schoonjans

BACKGROUND AND AIMS: Liver inflammation, fibrosis, and dyslipidemia are common features in patients with chronic hepatitis C virus (HCV) infection. Because peroxisome proliferator-activated receptor alpha (PPARalpha) is highly expressed in the liver and is ...

2005

Cylindrical fiberoptic light diffuser for medical applications

Hubert van den Bergh

BACKGROUND AND OBJECTIVE: A cylindrical light diffuser has been developed mainly for medical applications, including photodynamic therapy (PDT), in particular interstitial PDT, PDT of the bronchi, or intravascular PDT. STUDY DESIGN/MATERIALS AND METHODS: T ...

1996

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