Publication
Single-photon detector arrays for time-resolved fluorescence imaging
Publications associées (76)
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Major advances in silicon pixel detectors, with outstanding timing performance, have recently attracted significant attention in the community. In this work we present and discuss the use of state-of-the-art Geiger-mode APDs, also known as single-photon av ...
FRONTIERS MEDIA SA2022Large-Format Time-Gated SPAD Cameras for Real-Time Phasor-Based FLIM
Fluorescence lifetime imaging microscopy (FLIM) is an imaging modality often used to monitor biochemical properties of a cell or a tissue. In addition to conventional fluorescence microscopy features, such as selective labeling and non-invasiveness, FLIM e ...
EPFL2021Parameter-free rendering of single-molecule localization microscopy data for parameter-free resolution estimation
Aleksandra Radenovic, Adrien Charles-François Raymond Descloux, Kristin Stefanie Grussmayer
Localization microscopy is a super-resolution imaging technique that relies on the spatial and temporal separation of blinking fluorescent emitters. These blinking events can be individually localized with a precision significantly smaller than the classic ...
2021Megapixel SPAD cameras for time-resolved applications
Progress in optics technology has enriched our daily lives in many ways. Various types of single-photon detector technologies have emerged in the last century. Among these, single-photon avalanche diode (SPAD) technology outperforms other detectors for its ...
EPFL2021Multispectral image sensor and method for fabrication of an image sensor
The present invention relates to a multispectral image sensor having a pixel array for detecting images with light components in different wavelength ranges, comprising a plurality of imaging layers each embedded in a semiconductor substrate, wherein in ea ...
2020High-speed multiplane structured illumination microscopy of living cells using an image-splitting prism
Theo Lasser, Aleksandra Radenovic, Vytautas Navikas, Tomas Lukes, Adrien Charles-François Raymond Descloux
Super-resolution structured illumination microscopy (SR-SIM) can be conducted at video-rate acquisition speeds when combined with high-speed spatial light modulators and sCMOS cameras, rendering it particularly suitable for live-cell imaging. If, however, ...
2020Single-photon avalanche diode imagers in biophotonics: review and outlook
Edoardo Charbon, Claudio Bruschini, Ivan Michel Antolovic, Harald Arjan Robert Homulle, Samuel Burri
Single-photon avalanche diode (SPAD) arrays are solid-state detectors that offer imaging capabilities at the level of individual photons, with unparalleled photon counting and time-resolved performance. This fascinating technology has progressed at a very ...
2019Optical-stack optimization for improved SPAD photon detection efficiency
Edoardo Charbon, Claudio Bruschini, Ivan Michel Antolovic, Ekin Kizilkan, Rolando Ferrini, Arin Can Ülkü, Scott Anthony Lindner, Marc Schnieper, Frédéric Zanella
Single-photon avalanche diodes (SPADs) are direct photon-to-digital detectors that enable scalable arrays with Poisson-limited signal-to-noise ratio and picosecond timing resolution. However, SPAD detectors require a guard-ring structure to prevent lateral ...
2019A 30-frames/s, 252 x 144 SPAD Flash LiDAR With 1728 Dual-Clock 48.8-ps TDCs, and Pixel-Wise Integrated Histogramming
Edoardo Charbon, Ivan Michel Antolovic, Chunmin Zhang, Scott Anthony Lindner, Juan Mata Pavia, Martin Wolf
A 252 x 144 single-photon avalanche diode (SPAD) pixel sensor, called Ocelot, is reported for light detection and ranging (LiDAR). The sensor, fabricated in the 180-nm CMOS technology, features 1728 12-bit time-to-digital converters (TDCs) with 48.8-ps res ...
IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC2019Oscillator arrangement for time-to-digital converter for large array of time-of-flight image sensor devices
Edoardo Charbon, Preethi Padmanabhan, Augusto Ronchini Ximenes
An oscillator arrangement for time-to-digital converters for a 3D image sensor device includes a plurality of oscillators arranged as an array each oscillator being associated to one time-to-digital converter, and at least one coupling unit respectively ar ...
2019