Publication
Label-free, direct DNA detection by means of a standard CMOS electronic chip
Publications associées (65)
Electronic readout of DNA amplification in nanoliter chambers. Strategies towards highly parallel semiconductor-based nucleic acid amplification testing.
Polymerase chain reaction (PCR) has been the most significant driver in the field of nucleic acid testing (NAT) since its invention. Popularized as an abbreviation by the Covid-19 pandemic, PCR-based methods are the gold standard in the field of diagnostic ...
EPFL2023Thermal and Voltage-Aware Performance Management of 3D MPSoCs with Flow Cell Arrays and Integrated SC Converters
David Atienza Alonso, Marina Zapater Sancho, Giovanni Ansaloni, Alexandre Sébastien Julien Levisse, Halima Najibi
Flow cell arrays (FCAs) concurrently provide efficient on-chip liquid cooling and electrochemical power generation. This technology is especially promising for three-dimensional multi-processor systems-on-chip (3D MPSoCs) realized in deeply scaled technolo ...
2022Polydimethylsiloxane microstructure-induced acoustic streaming for enhanced ultrasonic DNA fragmentation on a microfluidic chip
Martinus Gijs, Thomas Lehnert, Lin Sun
Next-generation sequencing (NGS) is an essential technology for DNA identification in genomic research. DNA fragmentation is a critical step for NGS and doing this on-chip is of great interest for future integrated genomic solutions. Here we demonstrate fa ...
ROYAL SOC CHEMISTRY2022Development of a large-area, light-weight module using the MALTA monolithic pixel detector
Edoardo Charbon, Francesco Piro, Ashish Sharma
The MALTA pixel chip is a 2 cm x 2 cm large monolithic pixel detector developed in the Tower 180 nm imaging process. The chip contains four CMOS transceiver blocks at its sides which allow chip-to-chip data transfer. The power pads are located mainly at th ...
ELSEVIER2022Real-Time Multi-Ion Detection in the Sweat Concentration Range Enabled by Flexible, Printed, and Microfluidics-Integrated Organic Transistor Arrays
Danick Briand, Silvia Demuru, Brince Paul Kunnel
Organic electrochemical transistors (OECTs) show remarkable promise as biosensors, thanks to their high signal amplification, simple architecture, and the intrinsic flexibility of the organic material. Despite these properties, their use for real-time sens ...
WILEY2020Learning-Based Hardware Design for Data Acquisition Systems
This multidisciplinary research work aims to investigate the optimized information extraction from signals or data volumes and to develop tailored hardware implementations that trade-off the complexity of data acquisition with that of data processing, conc ...
EPFL2018Impedance-based real-time position sensor for lab-on-a-chip devices
Philippe Renaud, Harald Van Lintel, Jonathan Bastien Cottet
This paper presents the theoretical and experimental development of an integrated position sensor for lab-on-a-chip devices. The interest for single cell analysis is growing. However, this requires monitoring and controlling cell displacements in real time ...
20183D-Stacked CMOS SPAD Image Sensors: Technology and Applications
Edoardo Charbon, Claudio Bruschini, Myung Jae Lee
3Dstacked CMOS SPAD based image sensors hold the promise for better sensitivity and more functionality per pixel. The technology enables to separate detection from computation onto different chips, or tiers, that are stacked onto one another. One advantage ...
IEEE2018PowerCool: Simulation of Cooling and Powering of 3D MPSoCs with Integrated Flow Cell Arrays
David Atienza Alonso, Marina Zapater Sancho, Arvind Raj Mahankali Sridhar, Mohamed Mostafa Sabry Aly, Artem Andreev, Bruno Michel
Integrated Flow-Cell Arrays (FCAs) represent a combination of integrated liquid cooling and on-chip power generation, converting chemical energy of the flowing electrolyte solutions to electrical energy. The FCA technology provides a promising way to addre ...
Institute of Electrical and Electronics Engineers2017Ten years of biophotonics single-photon SPAD imager applications: retrospective and outlook, Multiphoton Microscopy in the Biomedical Sciences XVII
Edoardo Charbon, Claudio Bruschini, Harald Arjan Robert Homulle
SPAD (single-photon avalanche diode) arrays are single-photon imagers that can provide unparalleled timeresolved sensing performance. Since their inception in standard CMOS technologies (2003), a host of architectures and target applications have been expl ...
2017