The present invention relates to a method for the manufacture of a peptidic folding precursor (Switch-Peptide) stable and soluble at physiological conditions, derived from a peptide having a potential for self-assembling and fibrillogenesis. Another object of the invention is to provide a tool for the quantitative, controlled in vitro study of fibrillogenesis and its inhibition of peptides involved in degenerative diseases.
Jérôme Baudry, Ion-Gabriel Mihailescu
Herbert Shea, Vito Cacucciolo, Krishna Manaswi Digumarti
Pierre Gönczy, Niccolo Banterle