The present invention relates to a method for the manufacture of a peptidic folding precursor (Switch-Peptide) stable and soluble at physiological conditions, derived from a peptide having a potential for self-assembling and fibrillogenesis. Another object of the invention is to provide a tool for the quantitative, controlled in vitro study of fibrillogenesis and its inhibition of peptides involved in degenerative diseases.
Pierre Gönczy, Niccolo Banterle
Herbert Shea, Vito Cacucciolo, Krishna Manaswi Digumarti
Jérôme Baudry, Ion-Gabriel Mihailescu