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Removing geometrical details from a complex domain is a classical operation in computer aided design for simulation and manufacturing. This procedure simplifies the meshing process, and it enables faster simulations with less memory requirements. However, depending on the partial differential equation that one wants to solve in the geometrical model of interest, removing some important geometrical features may greatly impact the solution accuracy. For instance, in solid mechanics simulations, such features can be holes or fillets near stress concentration regions. Unfortunately, the effect of geometrical simplification on the accuracy of the problem solution is often neglected, because its analysis is a time-consuming task that is often performed manually, based on the expertise of engineers. It is therefore important to have a better understanding of the effect of geometrical model simplification, also called defeaturing, to improve our control on the simulation accuracy along the design and analysis phase.In this thesis, we formalize the process of defeaturing, and we analyze its impact on the accuracy of solutions of some partial differential problems. To achieve this goal, we first precisely define the error between the problem solution defined in the exact geometry, and the one defined in the simplified geometry. Then, we introduce an a posteriori estimator of the energy norm of this error. This allows us to reliably and efficiently control the error coming from the addition or the removal of geometrical features. We subsequently consider a finite element approximation of the defeatured problem, and the induced numerical error is integrated to the proposed defeaturing error estimator. In particular, we address the special case of isogeometric analysis based on (truncated) hierarchical B-splines, in possibly trimmed and multipatch geometries. In this framework, we derive a reliable a posteriori estimator of the overall error, i.e., of the error between the exact solution defined in the exact geometry, and the numerical solution defined in the defeatured geometry.We then propose a two-fold adaptive strategy for analysis-aware defeaturing, which starts by considering a coarse mesh on a fully-defeatured computational domain. On the one hand, the algorithm performs classical finite element mesh refinements in a (partially) defeatured geometry. On the other hand, the strategy also allows for geometrical refinement. That is, at each iteration, the algorithm is able to choose which missing geometrical features should be added to the simplified geometrical model, in order to obtain a more accurate solution.Throughout the thesis, we validate the presented theory, the properties of the aforementioned estimators and the proposed adaptive strategies, thanks to an extensive set of numerical experiments.
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