RNA Metabolism: ALS Genetics

In course

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Description

This lecture delves into the genetics of Amyotrophic Lateral Sclerosis (ALS), focusing on RNA metabolism and the role of proteins like TDP-43 and FUS/TLS. It covers mutations, oligomerization, cytosolic relocalization, stress granules, and the impact of C9orf72 hexanucleotide repeat expansion. The talk explores the formation of toxic dipeptide-repeat proteins, nucleocytoplasmic transport blockade, and potential therapeutic approaches.

Instructors (3)

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Official source

https://mediaspace.epfl.ch/media/0_5cuit5wd

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Ontological neighbourhood

Biology

Genetics: Molecular genetics

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