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Explores telomere syndromes, telomerase expression, end replication problems, telomere length during aging, defects in telomerase genes, and mouse models.
Explores replicative immortality in cancer cells, focusing on telomere erosion, telomerase activity, and the role of p53 in maintaining genomic stability.
Explores cellular senescence mechanisms induced by mitogenic signals, DNA damage, and oncogenes, emphasizing the role of key regulatory proteins and the impact on cell division.
Examines how a receptor regulates proteostasis in C. elegans, emphasizing the importance of maintaining cellular function and preventing protein misfolding diseases.
