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Concept
Polyethylene glycol
Summary
Chembox
| Verifiedfields = changed
| Watchedfields = changed
| verifiedrevid = 477163023
| Name =
| ImageFile = PEG Structural Formula V1.svg
| IUPACName = poly(oxyethylene) {structure-based}, poly(ethylene oxide) {source-based}
| OtherNames = Kollisolv, Carbowax, GoLYTELY, GlycoLax, Fortrans, TriLyte, Colyte, Halflytely, macrogol, MiraLAX, MoviPrep
| SystematicName =
| Section1 =
| Section2 = Chembox Properties
| Formula = C2nH4n+2On+1
| MolarMass = nowrap|44.05n + 18.02 g/mol
| Appearance =
| Density = 1.125
| MeltingPt =
| BoilingPt =
| Solubility =
| Section3 =
| Section4 =
| Section5 =
| Section6 =
| Section7 =
Polyethylene glycol (PEG; ˌpɒliˈɛθəlˌiːn_ˈɡlaɪˌkɒl,-ˈɛθɪl-,-ˌkɔːl) is a polyether compound derived from petroleum with many applications, from industrial manufacturing to medicine. PEG is also known as polyethylene oxide (PEO) or polyoxyethylene (POE), depending on its molecular weight. The structure of PEG is commonly expressed as H−(O−CH2−CH2)n−OH.
Macrogol and PEGylation
Pharmaceutical-grade PEG is used as an excipient in many pharmaceutical products, in oral, topical, and parenteral dosage forms.
PEG is the basis of a number of laxatives (as MiraLax, RestoraLAX, etc.). Whole bowel irrigation with polyethylene glycol and added electrolytes is used for bowel preparation before surgery or colonoscopy or for children with constipation. Macrogol (with brand names such as Laxido, GoLytely and Miralax) is the generic name for polyethylene glycol used as a laxative. The name may be followed by a number which represents the average molecular weight (e.g. macrogol 3350, macrogol 4000 or macrogol 6000).
The possibility that PEG could be used to fuse axons is being explored by researchers studying peripheral nerve and spinal cord injury.
An example of PEG hydrogels (see Biological uses section) in a therapeutic has been theorized by Ma et al. They propose using the hydrogel to address periodontitis (gum disease) by encapsulating stem cells in the gel that promote healing in the gums.
Official source
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Ethylene oxide
Ethylene oxide is an organic compound with the formula . It is a cyclic ether and the simplest epoxide: a three-membered ring consisting of one oxygen atom and two carbon atoms. Ethylene oxide is a colorless and flammable gas with a faintly sweet odor. Because it is a strained ring, ethylene oxide easily participates in a number of addition reactions that result in ring-opening. Ethylene oxide is isomeric with acetaldehyde and with vinyl alcohol. Ethylene oxide is industrially produced by oxidation of ethylene in the presence of a silver catalyst.
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A liposome is a small artificial vesicle, spherical in shape, having at least one lipid bilayer. Due to their hydrophobicity and/or hydrophilicity, biocompatibility, particle size and many other properties, liposomes can be used as drug delivery vehicles for administration of pharmaceutical drugs and nutrients, such as lipid nanoparticles in mRNA vaccines, and DNA vaccines. Liposomes can be prepared by disrupting biological membranes (such as by sonication).
Polyethylene glycol
Chembox | Verifiedfields = changed | Watchedfields = changed | verifiedrevid = 477163023 | Name = | ImageFile = PEG Structural Formula V1.svg | IUPACName = poly(oxyethylene) {structure-based}, poly(ethylene oxide) {source-based} | OtherNames = Kollisolv, Carbowax, GoLYTELY, GlycoLax, Fortrans, TriLyte, Colyte, Halflytely, macrogol, MiraLAX, MoviPrep | SystematicName = | Section1 = | Section2 = Chembox Properties | Formula = C2nH4n+2On+1 | MolarMass = nowrap|44.05n + 18.02 g/mol | Appearance = | Density = 1.
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