Publications related to Electrophysiology

We propose centralized brain observatories for large-scale recordings of neural activity in mice and non-human primates coupled with cloud-based data analysis and sharing. Such observatories will advance reproducible systems neuroscience and democratize ac ...

CELL PRESS2022

In-Cell Quantification of Drugs by Magic-Angle Spinning Dynamic Nuclear Polarization NMR

David Lyndon Emsley, Pierrick Berruyer, Andrea Bertarello

The determination of intracellular drug concentrations can provide a better understanding of the drug function and efficacy. Ideally, this should be performed nondestructively, with no modification of either the drug or the target, and with the capability ...

AMER CHEMICAL SOC2022

A Computational Study of the Electrophysiological Substrate in Patients Suffering From Atrial Fibrillation

Alfio Quarteroni, Andrea Manzoni

In the context of cardiac electrophysiology, we propose a novel computational approach to highlight and explain the long-debated mechanisms behind atrial fibrillation (AF) and to reliably numerically predict its induction and sustainment. A key role is pla ...

FRONTIERS MEDIA SA2021

Influence of Oxidative Stress on Time-Resolved Oxygen Detection by [Ru(Phen)3]2+ In Vivo and In Vitro

Georges Wagnières, Veronika Huntosova

Detection of tissue and cell oxygenation is of high importance in fundamental biological and in many medical applications, particularly for monitoring dysfunction in the early stages of cancer. Measurements of the luminescence lifetimes of molecular probe ...

2021

Cell-type-specific nicotinic input disinhibits mouse barrel cortex during active sensing

Carl Petersen, Sylvain Crochet, Célia Roxane Gasselin, Benoît Hohl

Fast synaptic transmission relies upon the activation of ionotropic receptors by neurotransmitter release to evoke postsynaptic potentials. Glutamate and GABA play dominant roles in driving highly dynamic activity in synaptically connected neuronal circuit ...

CELL PRESS2021

HippoUnit: A software tool for the automated testing and systematic comparison of detailed models of hippocampal neurons based on electrophysiological data

Eilif Benjamin Muller, Werner Alfons Hilda Van Geit, Armando Romani, Szabolcs Kali, Carmen Alina Lupascu, Rosanna Migliore, Luca Leonardo Bologna, Sàra Sàray, Shailesh Appukuttan

Anatomically and biophysically detailed data-driven neuronal models have become widely used tools for understanding and predicting the behavior and function of neurons. Due to the increasing availability of experimental data from anatomical and electrophys ...

PUBLIC LIBRARY SCIENCE2021

Two-stage Hardware-Friendly Epileptic Seizure Detection Method with a Dynamic Feature Selection

Alexandre Schmid, Keyvan Farhang Razi

A novel low-complexity method of detecting epileptic seizures from intracranial encephalography (iEEG) signals is presented. In the proposed algorithm, coastline, energy and nonlinear energy features of iEEG signals are extracted in a patient-specific two- ...

IEEE2021

Data integration for the numerical simulation of cardiac electrophysiology

Alfio Quarteroni, Andrea Manzoni, Luca Dede', Stefano Pagani

The increasing availability of extensive and accurate clinical data is rapidly shaping cardiovascular care by improving the understanding of physiological and pathological mechanisms of the cardiovascular system and opening new frontiers in designing thera ...

WILEY2021

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Electrophysiology

Next-generation brain observatories

Dopamine Dynamics in Reward-based Learning

In-Cell Quantification of Drugs by Magic-Angle Spinning Dynamic Nuclear Polarization NMR

A Computational Study of the Electrophysiological Substrate in Patients Suffering From Atrial Fibrillation

Influence of Oxidative Stress on Time-Resolved Oxygen Detection by [Ru(Phen)3]2+ In Vivo and In Vitro

Cell-type-specific nicotinic input disinhibits mouse barrel cortex during active sensing

HippoUnit: A software tool for the automated testing and systematic comparison of detailed models of hippocampal neurons based on electrophysiological data

Predicting task performance from biomarkers of mental fatigue in global brain activity

Two-stage Hardware-Friendly Epileptic Seizure Detection Method with a Dynamic Feature Selection

Data integration for the numerical simulation of cardiac electrophysiology

Graph Chatbot

Chat with Graph Search

Next-generation brain observatories

Influence of Oxidative Stress on Time-Resolved Oxygen Detection by [Ru(Phen)3]2+ In Vivo and In Vitro

In-Cell Quantification of Drugs by Magic-Angle Spinning Dynamic Nuclear Polarization NMR

Dopamine Dynamics in Reward-based Learning

Cell-type-specific nicotinic input disinhibits mouse barrel cortex during active sensing

HippoUnit: A software tool for the automated testing and systematic comparison of detailed models of hippocampal neurons based on electrophysiological data

Data integration for the numerical simulation of cardiac electrophysiology

A Computational Study of the Electrophysiological Substrate in Patients Suffering From Atrial Fibrillation

Predicting task performance from biomarkers of mental fatigue in global brain activity

Two-stage Hardware-Friendly Epileptic Seizure Detection Method with a Dynamic Feature Selection