Mathematical psychology

Mathematical psychology is an approach to psychological research that is based on mathematical modeling of perceptual, thought, cognitive and motor processes, and on the establishment of law-like rules that relate quantifiable stimulus characteristics with quantifiable behavior (in practice often constituted by task performance). The mathematical approach is used with the goal of deriving hypotheses that are more exact and thus yield stricter empirical validations. There are five major research areas in mathematical psychology: learning and memory, perception and psychophysics, choice and decision-making, language and thinking, and measurement and scaling. Although psychology, as an independent subject of science, is a more recent discipline than physics, the application of mathematics to psychology has been done in the hope of emulating the success of this approach in the physical sciences, which dates back to at least the seventeenth century. Mathematics in psychology is used extensively roughly in two areas: one is the mathematical modeling of psychological theories and experimental phenomena, which leads to mathematical psychology, the other is the statistical approach of quantitative measurement practices in psychology, which leads to psychometrics. As quantification of behavior is fundamental in this endeavor, the theory of measurement is a central topic in mathematical psychology. Mathematical psychology is therefore closely related to psychometrics. However, where psychometrics is concerned with individual differences (or population structure) in mostly static variables, mathematical psychology focuses on process models of perceptual, cognitive and motor processes as inferred from the 'average individual'. Furthermore, where psychometrics investigates the stochastic dependence structure between variables as observed in the population, mathematical psychology almost exclusively focuses on the modeling of data obtained from experimental paradigms and is therefore even more closely related to experimental psychology, cognitive psychology, and psychonomics.

About this result

This page is automatically generated and may contain information that is not correct, complete, up-to-date, or relevant to your search query. The same applies to every other page on this website. Please make sure to verify the information with EPFL's official sources.

Related publications (3)

Related concepts (7)

Related courses (19)

Related lectures (168)

Mathematical Modeling of T-Cell Experimental Data

Irina Baltcheva

T lymphocytes (T cells) are key components of the adaptive immune system. These cells are able to recognize an enormous variety of pathogens thanks to the great specificity of their trans-membrane proteins, the T cell receptors (TCRs). TCR diversity is created during T cell maturation in the thymus by somatic gene-segment rearrangements and random nucleotide additions or deletions. Out of all possible T cell clones bearing specific TCRs, only a small fraction are successfully released in peripheral blood as the result of clonal selection. Among the selected clones, some self-reactive cells with the capacity to induce an auto-immune disease are erroneously released in periphery. To compensate for this functional flaw, the immune system has developed peripheral control mechanisms. One of them are regulatory T cells that are specialized in the control of harmful self-reactive clones. In this thesis, we combine mathematical modeling and experimental data to address immunological questions related to the dynamics of regulatory T cells and to the measurement of the structural diversity of T cell receptors. The dissertation is split into two main parts. In the first part, we model the lifelong dynamics of human regulatory T cells (Tregs). Despite their limited proliferation capacity, Tregs constitute a population maintained over the entire lifetime of an individual. The means by which Tregs sustain a stable pool in vivo are controversial. We define a novel mathematical model that we use to evaluate several biological scenarios about the origins and the proliferation capacity of two subsets of Tregs: precursor CD4+CD25+-CD45RO- and mature CD4+CD25+CD45RO+ cells. The lifelong dynamics of Tregs are described by a set of ordinary differential equations, driven by a stochastic process representing the major immune reactions involving these cells. Most of the parameters are considered as random variables having an a priori distribution. The likelihood of a scenario is estimated using Monte Carlo simulations. The model dynamics are validated with data from human donors of different ages. Analysis of the data led to the identification of two properties of the dynamics: (a) the equilibrium in the CD4+CD25+ Tregs population is maintained over both precursor and mature Tregs pools together, and (b) the ratio between precursor and mature Tregs is inverted in the early years of adulthood. Then, using the model, we identified four biologically relevant scenarios that have the above properties: (1) if the unique source of mature Tregs is the antigendriven differentiation of precursors that acquire the mature profile in the periphery, then the proliferation of Tregs is essential for the development and the maintenance of the pool; if there exist other sources of mature Tregs, such as (2) a homeostatic regulation, (3) a thymic migration, or (4) a peripheral conversion of effectors into Tregs, then the antigen-induced proliferation is not necessary for the development of a stable pool of Tregs. In the second part of the dissertation, we address the general question of TCR diversity by improving the interpretation of AmpliCot, an experimental technique that aims at the diversity measurement of nucleic acid sequences. This procedure has the advantage over other cloning and sequencing techniques of being time- and expense- effective. In short, a fluorescent dye that binds double-stranded DNA is added to a sample of PCR-amplified DNA. The sample is melted, such that the DNA becomes single-stranded, and then re-annealed under stringent conditions. The annealing kinetics, measured in terms of fluorescence intensity, are a function of the diversity and of the concentration of the sample and have been interpreted assuming second order kinetics. Using mathematical modeling, we show that a more detailed model, involving heteroduplex- and transient-duplex formation, leads to significantly better fits of experimental data. Moreover, the new model accounts for the diversity-dependent fluorescence loss that is typically observed. As a consequence, we show that the original method for interpreting the results of AmpliCot experiments should be applied with caution. We suggest alternative methods for diversity extrapolation of a sample.

EPFL2010

Gamma Oscillations in a Nonlinear Regime: A Minimal Model Approach Using Heterogeneous Integrate-and-Fire Networks

Brice Bathellier

Fast oscillations and in particular gamma-band oscillation (20-80 Hz) are commonly observed during brain function and are at the center of several neural processing theories. In many cases, mathematical analysis of fast oscillations in neural networks has been focused on the transition between irregular and oscillatory firing viewed as an instability of the asynchronous activity. But in fact, brain slice experiments as well as detailed simulations of biological neural networks have produced a large corpus of results concerning the properties of fully developed oscillations that are far from this transition point. We propose here a mathematical approach to deal with nonlinear oscillations in a network of heterogeneous or noisy integrate-and-fire neurons connected by strong inhibition. This approach involves limited mathematical complexity and gives a good sense of the oscillation mechanism, making it an interesting tool to understand fast rhythmic activity in simulated or biological neural networks. A surprising result of our approach is that under some conditions, a change of the strength of inhibition only weakly influences the period of the oscillation. This is in contrast to standard theoretical and experimental models of interneuron network gamma oscillations (ING), where frequency tightly depends on inhibition strength, but it is similar to observations made in some in vitro preparations in the hippocampus and the olfactory bulb and in some detailed network models. This result is explained by the phenomenon of suppression that is known to occur in strongly coupled oscillating inhibitory networks but had not yet been related to the behavior of oscillation frequency.

Massachusetts Institute of Technology Press2008

A Mathematical Model Approach to Estimate and Forecast Electronic Waste: Case Studies of Delhi and Switzerland

Preeti Loonker

2007

Mathematical psychology

Behavioural sciences

The behavioural sciences explore the cognitive processes within organisms and the behavioural interactions between organisms in the natural world. It involves the systematic analysis and investigation of human and animal behaviour through naturalistic observation, controlled scientific experimentation and mathematical modeling. It attempts to accomplish legitimate, objective conclusions through rigorous formulations and observation. Examples of behavioural sciences include psychology, psychobiology, anthropology, economics, and cognitive science.

Computational neuroscience

Computational neuroscience (also known as theoretical neuroscience or mathematical neuroscience) is a branch of neuroscience which employs mathematical models, computer simulations, theoretical analysis and abstractions of the brain to understand the principles that govern the development, structure, physiology and cognitive abilities of the nervous system. Computational neuroscience employs computational simulations to validate and solve mathematical models, and so can be seen as a sub-field of theoretical neuroscience; however, the two fields are often synonymous.

MGT-602: Mathematical models in supply chain management

Over the past decade, supply chain management has drawn enormous attention by industry and academia alike. Given an increasingly global economy, pronounced trends towards outsourcing and advances in i

ME-221: Dynamical systems

Provides the students with basic notions and tools for the analysis of dynamic systems. Shows them how to develop mathematical models of dynamic systems and perform analysis in time and frequency doma

BIO-221: Cell and developmental biology for engineers

Students will learn essentials of cell and developmental biology with an engineering mind set, with an emphasis on animal model systems and quantitative approaches.

Spin Glasses: Fully Connected PHYS-642: Statistical physics for optimization & learning

Covers the basics of spin glasses and the mathematical equations used to model them.

Pen-and-paper exercises: Session 4 CS-452: Foundations of software

Focuses on pen-and-paper exercises in computational analysis and problem-solving strategies.

Oil Convection Study ME-201: Continuum mechanics

Studies the convection of oil in a baking dish.