Concept

Transposable element

Related publications (171)

As Time Goes by: KRABs Evolve to KAP Endogenous Retroelements

Retroelements, constituting about 50% of the human genome, both contribute to its evolution and threaten its integrity and are thus silenced during development. Jacobs et al. (2014) identify sequence-specific KRAB-ZNF proteins that repress subsets of L1 an ...

Elsevier2014

Microbiota-Induced Changes in Drosophila melanogaster Host Gene Expression and Gut Morphology

Bruno Lemaitre, Nichole Broderick

To elucidate mechanisms underlying the complex relationships between a host and its microbiota, we used the genetically tractable model Drosophila melanogaster. Consistent with previous studies, the microbiota was simple in composition and diversity. Howev ...

American Society for Microbiology2014

Evolutionally dynamic L1 regulation in embryonic stem cells

Didier Trono, Priscilla Turelli, Julien Léonard Duc, Marc Samuel Friedli, Adamantia Kapopoulou, Gabriela Ecco, Andrea Coluccio, Suk Min Jang

Mobile elements are important evolutionary forces that challenge genomic integrity. Long interspersed element-1 (L1, also known as LINE-1) is the only autonomous transposon still active in the human genome. It displays an unusual pattern of evolution, with ...

Cold Spring Harbor Lab Press, Publications Dept2014

Temporal dynamics and developmental memory of 3D chromatin architecture at Hox gene loci

Denis Duboule, Marion Leleu, Daniël Noordermeer, Patrick Schorderet

Hox genes are essential regulators of embryonic development. Their step-wise transcriptional activation follows their genomic topology and the various states of activation are subsequently memorized into domains of progressively overlapping gene products. ...

Elife Sciences Publications Ltd2014

Modeling of transcription mechanisms in mammals from kinetic measurements in single cells

Benjamin Zoller

In mammals, transcription was observed to occur predominantly in bursts, resulting from short and intense periods of gene transcription interspersed by longer silent periods. In order to elucidate the causes and the consequences of discontinuous transcript ...

EPFL2014

A Dual Program for Translation Regulation in Cellular Proliferation and Differentiation

Sebastian Martin Waszak

A dichotomous choice for metazoan cells is between proliferation and differentiation. Measuring tRNA pools in various cell types, we found two distinct subsets, one that is induced in proliferating cells, and repressed otherwise, and another with the oppos ...

Cell Press2014

MAR Elements and Transposons for Improved Transgene Integration and Expression

Nicolas Mermod, Déborah Ley, Niamh Harraghy

Reliable and long-term expression of transgenes remain significant challenges for gene therapy and biotechnology applications, especially when antibiotic selection procedures are not applicable. In this context, transposons represent attractive gene transf ...

2013

Cues and regulatory pathways involved in natural competence and transformation in pathogenic and environmental Gram-negative bacteria

Melanie Blokesch, Patrick Martin Seitz

Bacterial genomics is flourishing, as whole-genome sequencing has become affordable, readily available, and rapid. As a result, it has become clear how frequently horizontal gene transfer (HGT) occurs in bacteria. The potential implications are highly sign ...

Wiley-Blackwell2013

RECURRENT AND RECENT SELECTIVE SWEEPS IN THE piRNA PATHWAY

Jeffrey David Jensen

Uncontrolled transposable element (TE) insertions and excisions can cause chromosome breaks and mutations with dramatic deleterious effects. The PIWI interacting RNA (piRNA) pathway functions as an adaptive TE silencing system during germline development. ...

Wiley-Blackwell2013

TRIM28 repression of retrotransposon-based enhancers is necessary to preserve transcriptional dynamics in embryonic stem cells

Didier Trono, Adamantia Kapopoulou, Andrea Corsinotti, Helen Mary Rowe, Johan Jakobsson

TRIM28 is critical for the silencing of endogenous retroviruses (ERVs) in embryonic stem (ES) cells. Here, we reveal that an essential impact of this process is the protection of cellular gene expression in early embryos from perturbation by cis-acting act ...

2013

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