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Concept
Repeated measures design
Résumé
Repeated measures design is a research design that involves multiple measures of the same variable taken on the same or matched subjects either under different conditions or over two or more time periods. For instance, repeated measurements are collected in a longitudinal study in which change over time is assessed.
Crossover study
A popular repeated-measures design is the crossover study. A crossover study is a longitudinal study in which subjects receive a sequence of different treatments (or exposures). While crossover studies can be observational studies, many important crossover studies are controlled experiments. Crossover designs are common for experiments in many scientific disciplines, for example psychology, education, pharmaceutical science, and health care, especially medicine.
Randomized, controlled, crossover experiments are especially important in health care. In a randomized clinical trial, the subjects are randomly assigned treatments. When such a trial is a repeated measures design, the subjects are randomly assigned to a sequence of treatments. A crossover clinical trial is a repeated-measures design in which each patient is randomly assigned to a sequence of treatments, including at least two treatments (of which one may be a standard treatment or a placebo): Thus each patient crosses over from one treatment to another.
Nearly all crossover designs have "balance", which means that all subjects should receive the same number of treatments and that all subjects participate for the same number of periods. In most crossover trials, each subject receives all treatments.
However, many repeated-measures designs are not crossovers: the longitudinal study of the sequential effects of repeated treatments need not use any "crossover", for example (Vonesh & Chinchilli; Jones & Kenward).
Limited number of participants—The repeated measure design reduces the variance of estimates of treatment-effects, allowing statistical inference to be made with fewer subjects.
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