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Publications associées (235)

GETPrime: a gene- or transcript-specific primer database for quantitative real-time PCR

Bart Deplancke, Jacques Rougemont, Fabrice David, Andreas Massouras, Alexandre Gattiker, Frederik Decouttere

The vast majority of genes in humans and other organisms undergo alternative splicing, yet the biological function of splice variants is still very poorly understood in large part because of the lack of simple tools that can map the expression profiles and ...

2011

Protein-Binding Microarray Analysis of Tumor Suppressor AP2 alpha Target Gene Specificity

Horst Vogel, Luigino Grasso, Jan Kerschgens, Tanja Egener-Kuhn, Nicolas Mermod, Hans-Anton Lehr

Cheap and massively parallel methods to assess the DNA-binding specificity of transcription factors are actively sought, given their prominent regulatory role in cellular processes and diseases. Here we evaluated the use of protein-binding microarrays (PBM ...

Public Library of Science2011

A polymorphism in the leptin gene promoter is associated with anemia in patients with HIV disease

Jacques Fellay, Amalio Telenti

To study factors associated with anemia and its effect on survival in HIV-infected persons treated with modern combined antiretroviral therapy (cART), we characterized the prevalence of anemia in the Veterans Aging Cohort Study (VACS) and used a candidate ...

2011

Development of an interactive genome browser to visualize and analyse large scale genomic data

Lucas Sinclair

Genomic bioinformatics is a growing and developing field. Indeed, data analysis is becoming an integrative and essential part of any quantitative biological experiment as the technologies evolve and the wet lab methods used generate larger and larger quant ...

2010

Visual backward masking deficits in schizophrenic patients are associated with polymorphisms in the nicotinic receptor α7 subunit gene (CHRNA7)

Michael Herzog, Maya Roinishvili

Visual backward masking (BM) deficits are often proposed to be trait markers for schizophrenia revealing the genetic underpinnings of the disease. Here, we show that, indeed, masking deficits in the shine-through effect are associated with polymorphisms in ...

2010

Sliding of rough surfaces and energy dissipation with a 3D multiscale approach

Jean-François Molinari, Guillaume Anciaux

The purpose of this paper is to present a novel approach to study sliding friction by the use of 3D multiscale coupling techniques. We highlight the difficulties of using multiscale schemes that couple molecular dynamics (MD) with finite elements to perfor ...

2010

Deciphering translation - a genome-wide analysis of translation in Escherichia coli

Vassily Hatzimanikatis, Julien Racle

Protein synthesis is one of the central elements in every living cell. For this process, mRNAs coding for genes are simultaneously competing for the same translation machinery (ribosomes and amino acids). But the ultimate determinants of cellular functions ...

2010

Genome-wide mRNA expression correlates of viral control in CD4+ T-cells from HIV-1-infected individuals

Jacques Fellay, Patrick Descombes, Amalio Telenti

There is great interindividual variability in HIV-1 viral setpoint after seroconversion, some of which is known to be due to genetic differences among infected individuals. Here, our focus is on determining, genome-wide, the contribution of variable gene e ...

2010

A dual promoter lentiviral vector for the in vivo evaluation of gene therapeutic approaches to axon regeneration after spinal cord injury

The identification of axon growth-promoting genes, and overexpression of these genes in central nervous system (CNS) neurons projecting to the spinal cord, has emerged as one potential approach to enhancing CNS regeneration. Assessment of the regenerative ...

2010

Expression analysis of novel striatal-enriched genes in Huntington disease

Selective degeneration of striatal neurons is a pathologic hallmark of Huntington disease (HD). The exact mechanism(s) behind this specific neurodegeneration is still unknown. Expression studies of diseased human post-mortem brain, as well as different mou ...

Oxford University Press2010

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