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This lecture covers the concept of hydropathicity and its relation to the interaction of amino acids with water. It explains how the hydrophobicity of molecules can be objectively measured using the partition coefficient. The lecture also delves into the properties and conventions associated with common amino acids found in proteins, discussing their hydropathy index, occurrence, and polarity. Additionally, it explores the hydrophobicity scale for identifying transmembrane helices and the role of amino acid residues in protein structures.