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Explores proximity-specific ribosome profiling and translational dynamics with high resolution, covering translation in different cells and the ER's role in protein synthesis.
Explores spatial regulation of ribosomal protein translation and the role of the ER in protein synthesis, covering advanced concepts and experimental designs.
Explores membrane protein quality control mechanisms at the ER, focusing on ERAD recognition, retrotranslocation, ubiquitination, and degradation of misfolded proteins.
Explores proteinopathy mapping, connecting proteotoxicity to intrinsic functions of aggregation-prone proteins, with a focus on alpha-synuclein and Parkinson's Disease.
Explores the evolution and function of protein-repair machineries, emphasizing the role of ATP-fueled unfolding machines in preventing protein aggregation and promoting proper folding.
