Cell Membrane Receptors: General Principles

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Pharmacodynamics: Ligand-Receptor Binding and Drug Effects

Explores ligand-receptor binding, drug effects, efficacy, potency, and biased agonism in pharmacodynamics.

Sustained Proliferation: RTK/PI3K/mTOR Pathway in Cancer

Explores the RTK/PI3K/mTOR pathway in cancer, inhibitors, completed trials, and effects of Akt/PKB on survival and proliferation.

Melanocytes and Hair Color Regulation

Examines paracrine communication in melanocytes, CAMP influence on hair color, Mc4R mutations, and fur phenotypes.

Post-translational Modifications of Proteins

Provides an overview of protein post-translational modifications, including phosphorylation, ubiquitination, and acylation.

Nuclear Receptors: Core Signaling

Explores nuclear receptors' core signaling and the impact of endocrine disruptors on the endocrine system, including the inhibitory effects of compounds like eugenol on the estrogen receptor.

Drug Targets: Receptors, Enzymes, and Transporters

Explores drug targets like receptors, enzymes, and transporters, focusing on top drug indications and receptor-mediated activation of G proteins.

Kinase Inhibitors: Types and Mechanisms

Explores kinase inhibitors, their types, mechanisms, and experimental evaluation, emphasizing the significance of covalent drugs in modern pharmaceutical research.

Fine-grained Patterning: Lateral Inhibition

Explores the development of the vulva in C. elegans and the intricate signaling pathways involved in inducing and inhibiting gene expression.

SEGREGATION of KINETIC REACTIVITY & BINDING AFFINITY

The paper focuses on the importance of reversible interactions to potency and mechanisms of drug resistance.

Cell Signalling: Eucaryotes

Explores cell signalling in eukaryotic cells, focusing on G proteins, Ras, and receptor tyrosine kinases.