Pharmacokinetic & Pharmacodynamic Studies

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Related lectures (32)

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Pharmacokinetic & Pharmacodynamic Evaluations

Covers the principles of pharmacokinetics and pharmacodynamics, including drug exposure-response relationships.

Pharmacokinetics: Drug Absorption and Distribution

Explores drug absorption, distribution, and clinical implications, focusing on salicylate poisoning and drug trapping in lysosomes.

Identifying Correct Target in Medical Chemistry

Explores target identification, efficacy, and safety in medical chemistry, emphasizing the importance of on-target specificity and drug design.

Pharmacokinetics Modeling: Zero and First-Order Kinetics

Explores pharmacokinetics modeling, covering zero and first-order kinetics, drug distribution, and key parameters for drug elimination.

Interrogating SAR: Medicinal Chemistry

Covers medicinal chemistry basics, high-throughput screening, lead discovery milestones, and compound selectivity in drug optimization.

Drug Targets: Adrenergic Signaling

Explores drug targets and adrenergic signaling, covering receptors, enzymes, and transporter proteins.

Interrogating SAR in Medical Chemistry

Delves into the fundamentals of medicinal chemistry, emphasizing the interrogation of Structure-Activity Relationships (SAR) in drug design.

Preclinical Animal Models: Selection & Rationale

Explores the selection and rationale of preclinical animal models in drug development, emphasizing the 10 to 15-year path to a marketed small-molecule drug.

Selective Drug Targeting Mechanisms

Explores selective drug targeting mechanisms, resistance development, tuberculosis incidence, BCR-ABL mutations, tyrosine kinase inhibitors, drug toxicity, interactions, and toxicology studies.

Peptide Therapeutics

Explores the development and advantages of peptide therapeutics, including conversion into peptidomimetics and solid phase peptide synthesis.