Médiation | EPFL Graph Search

La médiation est une pratique ou une discipline qui vise à définir l'intervention d'un tiers pour faciliter la circulation d'informations, éclaircir ou rétablir des relations. Ce tiers neutre, indépendant et impartial, est appelé médiateur. La définition de cette activité varie selon les contextes d'application. Néanmoins, des constantes existent à chaque fois qu'un tiers intervient pour faciliter une relation ou la compréhension d'une situation et des éléments de pédagogie et de qualité relationnelle se retrouvent dans les pratiques de la médiation. Un débat sur la définition de la médiation et de ses objectifs est animé par les courants d'influence qui habituellement interviennent dans le champ des conflits et de la « qualité de vie interpersonnelle » : religion et idéologie, juridique et réglementation, psychologie et psychothérapie, et philosophie et approche rationnelle de la médiation et des conflits généraux. Définition juridique en droit français La conception juri

Conduit, Patio, Waste: Mapping Environmental Relations in Bairro da Malagueira

Bárbara Maçães E Costa

The ongoing ecological crisis is reframing the common binary opposition between architecture and nature and provoking us to ask what kinds of buildings we collectively want to create for the ecosystems that we inhabit. The environment is not a neutral background, a natural scenery, or a container of pre-social resources; and architecture is not a collection of objects floating in a vacuum. Buildings and landscapes constitute each other dialectically. The environmental question in Western architecture had a peak moment during the contextualism debates of the 1950s and 60s, in the UK and Italy. They equated context with ideas such as ecological urbanism and habitat, or preesistenze ambientali and continuita . But by the 1970âs there was a shift from a sort of socio-biological determinism towards a more culturalist approach. Context became synonymous with historical context, and site-specificity was to be achieved less through a dialectical interplay with material reality than through a referential, typo-morphological approach. Gradually, a rift emerged: ecology became a matter of natural fact to be technologically calculated, and context became a matter of cultural identity to be narrated and deconstructed. From this point onwards, and in tandem with the rise of neoliberal commodification and its correlate ideology of postmodernism, Western architecture lost the ability to tackle the environmental question beyond the narrow scope of the individual architectural object. Before this split, the modernist tradition had attempted to address the built environment, and housing projects in particular, as a socio-ecological totality. Backed by large-scale funding initiatives from social-democratic states, human and non-human life could be understood dialectically, with the neighbourhood scale functioning as a mediating unit between the individual and the social. Alvaro Siza's Bairro da Malagueira was one of the last projects of this generation. It emerged from the very particular conditions of the 1974/75 Carnation Revolution and the state-sponsored housing program SAAL, a dual power structure made up of construction technical brigades and neighbourhood committees. During this process, the SAAL-Norte produced a series of projects focused on reinventing the typology of the ilha, and Alvaro Siza wrote a text considering the hypothesis of the proletarian island as basic element of the urban tissue. What was taken from these islands was less their stylistic or typological configuration than the system of environmental relations that they fostered, predicated on a series of threshold spaces and open interiorities. From Bairro da Malagueira, this thesis proposes a method for mapping environmental relations in architecture. It does so by identifying a series of thresholds, namely the conduit, the patio, and the waste, understood as structures that convert space into bounded associations, mediating between inside and outside, foreground and background, architecture and nature. Each threshold acts as a time-space frame with a specific magnitude of approximation, and each internalizes sets of social relations, such as class, gender and race, with corresponding modes of environmental production, namely the hidden backgrounds of territory, domesticity, and wilderness. Bairro da Malagueira hence becomes a template through which this thesis explores a dialectical understanding of architecture as an agent of environmental history.

EPFL2021

Perinatal Exposure to Bisphenol A Increases Adult Mammary Gland Progesterone Response and Cell Number

Ayyakkannu Ayyanan, Cathrin Brisken, Jacques Rougemont, Christina Schrick, Tamara Tanos

Bisphenol A [BPA, 2,2,-bis (hydroxyphenyl) propane] is one of the highest-volume chemicals produced worldwide. It is detected in body fluids of more than 90% of the human population. Originally synthesized as an estrogenic compound, it is currently utilized to manufacture food and beverage containers resulting in uptake with food and drinks. There is concern that exposure to low doses of BPA, defined as less than or equal to 5 mg/kg body weight /d, may have developmental effects on various hormone-responsive organs including the mammary gland. Here, we asked whether perinatal exposure to a range of low doses of BPA is sufficient to alter mammary gland hormone response later on in life, with a possible impact on breast cancer risk. To mimic human exposure, we added BPA to the drinking water of C57/Bl6 breeding pairs. Analysis of the mammary glands of their daughters at puberty showed that estrogen-dependent transcriptional events were perturbed and the number of terminal end buds, estrogen-induced proliferative structures, was altered in a dose-dependent fashion. Importantly, adult females showed an increase in mammary epithelial cell numbers comparable to that seen in females exposed to diethylbestrol, a compound exposure to which was previously linked to increased breast cancer risk. Molecularly, the mRNAs encoding Wnt-4 and receptor activator of nuclear factor ĸB ligand, two key mediators of hormone function implicated in control of mammary stem cell proliferation and carcinogenesis, showed increased induction by progesterone in the mammary tissue of exposed mice. Thus, perinatal exposure to environmentally relevant doses of BPA alters long-term hormone response that may increase the propensity to develop breast cancer.

Endocrine Society2011

Conduit, Patio, Waste: Mapping Environmental Relations in Bairro da Malagueira

Bárbara Maçães E Costa

EPFL2021