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Concept
Retinal
Summary
Retinal (also known as retinaldehyde) is a polyene chromophore. Retinal, bound to proteins called opsins, is the chemical basis of visual phototransduction, the light-detection stage of visual perception (vision).
Some microorganisms use retinal to convert light into metabolic energy. In fact, a recent study suggests most living organisms on our planet ~3 billion years ago used retinal to convert sunlight into energy rather than chlorophyll. Since retinal absorbs mostly green light and transmits purple light, this gave rise to the Purple Earth Hypothesis.
There are many forms of vitamin A — all of which are converted to retinal, which cannot be made without them. Retinal itself is considered to be a form of vitamin A when eaten by an animal. The number of different molecules that can be converted to retinal varies from species to species. Retinal was originally called retinene, and was renamed after it was discovered to be vitamin A aldehyde.
Vertebrate animals ingest retinal directly from meat, or they produce retinal from carotenoids — either from α-carotene or β-carotene — both of which are carotenes. They also produce it from β-cryptoxanthin, a type of xanthophyll. These carotenoids must be obtained from plants or other photosynthetic organisms. No other carotenoids can be converted by animals to retinal. Some carnivores cannot convert any carotenoids at all. The other main forms of vitamin A — retinol and a partially active form, retinoic acid — may both be produced from retinal.
Invertebrates such as insects and squid use hydroxylated forms of retinal in their visual systems, which derive from conversion from other xanthophylls.
Living organisms produce retinal by irreversible oxidative cleavage of carotenoids.
For example:
beta-carotene + O2 → 2 retinal,
catalyzed by a beta-carotene 15,15'-monooxygenase or a beta-carotene 15,15'-dioxygenase.
Just as carotenoids are the precursors of retinal, retinal is the precursor of the other forms of vitamin A.
Official source
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