Startup

Nagi Bioscience

Description

Nagi Bioscience, a spin-off from EPFL, specializes in pioneering Organism-on-Chip technologies for automated high-content screening of substances, offering a 3R alternative to animal testing. Their cutting-edge laboratory equipment enables end-to-end screenings on micro-organisms, ensuring standardization and reproducibility. By integrating their technology, companies can identify adverse toxicology early in the R&D pipeline, reducing late-stage failures and costs. Nagi's innovative solutions, such as SydLab(tm) ONE, provide powerful methodologies for assessing lifespan and healthspan measures in model systems like C. elegans, offering a more ethical and efficient approach to biological testing.

Official source

https://nagibio.ch

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Categories (6)

Related concepts (21)

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Related people (3)

Related publications (5)

Related units (11)

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Life extension

Life extension is the concept of extending the human lifespan, either modestly through improvements in medicine or dramatically by increasing the maximum lifespan beyond its generally-settled limit of 125 years. Several researchers in the area, along with "life extensionists", "immortalists" or "longevists" (those who wish to achieve longer lives themselves), postulate that future breakthroughs in tissue rejuvenation, stem cells, regenerative medicine, molecular repair, gene therapy, pharmaceuticals, and organ replacement (such as with artificial organs or xenotransplantations) will eventually enable humans to have indefinite lifespans (agerasia) through complete rejuvenation to a healthy youthful condition.

Alternatives to animal testing

Alternatives to animal testing are the development and implementation of test methods that avoid the use of live animals. There is widespread agreement that a reduction in the number of animals used and the refinement of testing to reduce suffering should be important goals for the industries involved. Two major alternatives to in vivo animal testing are in vitro cell culture techniques and in silico computer simulation.

Senescence

Senescence (sɪˈnɛsəns) or biological aging is the gradual deterioration of functional characteristics in living organisms. The word senescence can refer to either cellular senescence or to senescence of the whole organism. Organismal senescence involves an increase in death rates and/or a decrease in fecundity with increasing age, at least in the latter part of an organism's life cycle. Senescence is the inevitable fate of almost all multicellular organisms with germ-soma separation, but it can be delayed.

Animal testing

Animal testing, also known as animal experimentation, animal research, and in vivo testing, is the use of non-human animals in experiments that seek to control the variables that affect the behavior or biological system under study. This approach can be contrasted with field studies in which animals are observed in their natural environments or habitats. Experimental research with animals is usually conducted in universities, medical schools, pharmaceutical companies, defense establishments, and commercial facilities that provide animal-testing services to the industry.

Life expectancy

Life expectancy is a statistical measure of the estimate of the span of a life. The most commonly used measure is life expectancy at birth (LEB), which can be defined in two ways. Cohort LEB is the mean length of life of a birth cohort (in this case, all individuals born in a given year) and can be computed only for cohorts born so long ago that all their members have died. Period LEB is the mean length of life of a hypothetical cohort assumed to be exposed, from birth through death, to the mortality rates observed at a given year.

Aging

Ageing (or aging in American English) is the process of becoming older. The term refers mainly to humans, many other animals, and fungi, whereas for example, bacteria, perennial plants and some simple animals are potentially biologically immortal. In a broader sense, ageing can refer to single cells within an organism which have ceased dividing, or to the population of a species. In humans, ageing represents the accumulation of changes in a human being over time and can encompass physical, psychological, and social changes.

Cell biology

Cell biology (also cellular biology or cytology) is a branch of biology that studies the structure, function, and behavior of cells. All living organisms are made of cells. A cell is the basic unit of life that is responsible for the living and functioning of organisms. Cell biology is the study of the structural and functional units of cells. Cell biology encompasses both prokaryotic and eukaryotic cells and has many subtopics which may include the study of cell metabolism, cell communication, cell cycle, biochemistry, and cell composition.

Biology

Biology is the scientific study of life. It is a natural science with a broad scope but has several unifying themes that tie it together as a single, coherent field. For instance, all organisms are made up of cells that process hereditary information encoded in genes, which can be transmitted to future generations. Another major theme is evolution, which explains the unity and diversity of life. Energy processing is also important to life as it allows organisms to move, grow, and reproduce.

Applied sciences

The following outline is provided as an overview of and topical guide to applied science: Applied science – the branch of science that applies existing scientific knowledge to develop more practical applications, including inventions and other technological advancements. Science itself is the systematic enterprise that builds and organizes knowledge in the form of testable explanations and predictions about the universe. Applied cryptography – applications of cryptography.

Natural sciences

Natural science is one of the branches of science concerned with the description, understanding and prediction of natural phenomena, based on empirical evidence from observation and experimentation. Mechanisms such as peer review and repeatability of findings are used to try to ensure the validity of scientific advances. Natural science can be divided into two main branches: life science and physical science. Life science is alternatively known as biology, and physical science is subdivided into branches: physics, chemistry, earth science, and astronomy.

Nagi Bioscience

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Cross-species functional modules link proteostasis to human normal aging

Evolution of longevity improves immunity in Drosophila

NAD+ repletion improves mitochondrial and stem cell function and enhances life span in mice

NAD+ repletion improves mitochondrial and stem cell function and enhances life span in mice

Evolution of longevity improves immunity in Drosophila

Cross-species functional modules link proteostasis to human normal aging